CLINICAL APPLICATIONS   Provides Magnesium Bisglycinate Chelate for Optimal Absorption and GI Comfort High-Concentration Magnesium for Maximum Supports Helps Maintain Healthy Glucose Levels Improve Symptoms Such As Hyperactivity, Restlessness, Fidgeting And Body Rocking, Poor Concentration, And Noise Sensitivity Support Bone Health Promote Calm Magnesium is a mineral used by every organ in the body, especially the heart, muscles, and kidneys. By some estimates, up to 80 percent of Americans are not getting enough of this key mineral. Magnesium insufficiency has been implicated in a wide range of health challenges. Super Mag Powder delivers 300 mg magnesium bisglycinate chelate in a delicious, strawberry-lemonade flavored mix that can be added to any beverage. Magnesium bisglycinate was chosen for its proven enhanced absorption. In addition, the chelated form of magnesium bisglycinate used in this formula is gentle on the stomach. Research has demonstrated this form to be well-tolerated, causing less laxation potential than other forms of magnesium, such as oxide.1

Overview

Magnesium is an essential mineral that plays a critical role in the growth and development of healthy bones and it is involved in over 300 biochemical reactions including energy generation, muscle movement, proper hydration, and much more [1]. Furthermore, this mineral fuels the brain and eases the transfer of information through the central nervous system by imparting a soothing effect on the nerves and supporting the production of the key calming neurotransmitter, serotonin. ¹ In addition to influencing numerous processes, Mmagnesium levels are also a significant predictor of neurodevelopmental disorder complexity. This includes conditions such as attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). ² Children with ADHD not only have lower levels of magnesium, but clinical symptoms generally improve during periods of magnesium supplementation. ³ Furthermore, while magnesium levels are reduced in children with ASD ⁴ , symptoms of ASD can also be reduced when the diet is supplemented with magnesium ⁵ For children with ADHD or ASD, maintaining sufficient levels of brain energy and a calm nervous system are key areas to target, yet research shows that magnesium is one of the minerals that is commonly insufficient in children with these types of psychosocial and neurodevelopmental disorders. ⁶ In one study which assessed magnesium levels in typically developing children, those with ASD, and children with other neurodevelopmental disorders, the children with ASD or other disorders had significantly lower plasma magnesium levels than the healthy participants. ⁶ When magnesium is too low, cognitive ability becomes impaired, along with the attention span. In addition, issues such as aggression, fatigue, and a lack of concentration can worsen. ⁷ Conversely, parents and clinicians commonly report that supplementing the diet with magnesium helps improve their child’s sensory sensitivity, enhances sleep quality, heightens mood, and boosts cognitive function. ^6,8 Furthermore, children with ADHD and ASD often require larger quantities of magnesium than what their diet typically provides or their gut is able to absorb. Therefore, supplementation is a great way to supply the body with the amount of magnesium it needs to yield these important benefits.

Bioavailability: The Mineral Chelate Difference^†

The importance of bioavailability is obvious. If consuming a magnesium supplement has little effect on improving the body’s magnesium balance, there is no reason to ingest it. Signs of inferior mineral supplements include the use of cheap, poorly absorbed, rock-salt minerals like calcium carbonate and magnesium oxide (See Figure 1). These mineral forms slow and limit absorption, relying on adequate stomach acid to release magnesium ions which then enter the body via passive diffusion. And, because they tend to remain in the intestines longer, these forms of mineral supplements can cause intestinal distress such as constipation (calcium carbonate) or diarrhea (magnesium oxide). Super Mag Powder provides the additional benefit of highly absorbed, Albion® magnesium chelates. Albion® is the world leader in manufacturing highly bioavailable mineral chelates, a specialized form of minerals bound to amino acids. This patented process creates organic mineral compounds which use active absorption mechanisms in the gastrointestinal tract to greatly enhance mineral absorption. In a magnesium comparison study reported by Graff et al. at Weber State University, Albion®’s magnesium amino acid chelate had (See Figure 1)⁶:

1. 8.8 times greater absorption than magnesium oxide
2. 5.6 times greater absorption than magnesium sulfate
3. 2.3 times greater absorption than magnesium carbonate

1. At a dose of 400 mg, magnesium chelate significantly reduced or eliminated menstrual abdominal discomfort ⁷
2. Multiple double blind studies found urinary excretion of magnesium chloride higher than magnesium glycinate, proving superior absorption ^8-10
3. Magnesium glycinate is shown to have a reduced laxative effect when compared to other forms of magnesium ¹¹

Insulin Balance^†

Magnesium is integral for the transport of insulin from the bloodstream to cells. Increasing magnesium levels has been shown to maintain normal blood sugar levels. Diets with higher amounts of magnesium are associated with blood sugar balance, due to the role of magnesium in glucose metabolism. ^14-16 Most investigations of magnesium intake and insulin balance have been prospective cohort studies. A meta-analysis of seven of these studies, which included 286,668 patients, found that a 100 mg/day increase in total magnesium intake promoted insulin balance by a statistically significant 15%. ¹¹ Another meta-analysis of eight prospective cohort studies that followed 271,869 men and women for an extended period of time found a significant association between magnesium intake from food and insulin balance. ¹⁵

Bone Health^†

Magnesium is involved in bone formation and influences the activity of osteoblasts and osteoclasts, cells responsible for the breakdown and formation of bone. ¹⁸ Magnesium also impacts concentrations of parathyroid hormone and the active form of vitamin D, which are major regulators of bone homeostasis. Several population-based studies have found positive associations between magnesium intake and the state of bone strength and mineralization in men and women. ^19-2

Directions

Mix 1 scoop (5.7 grams) of Super Mag Powder with water or the beverage of your choice once daily or as recommended by your health care professional.

Super Mag Powder Dosage Instructions

Start at a low dose and slowly work up to the recommended dosage over 1-2 weeks. Mix powder with approx. 4-10 oz of beverage of choice. Increased dosage may be appropriate for some, please consult your healthcare provider.

Does Not Contain

Gluten, corn, yeast, artificial colors and flavors.

Cautions

If you are pregnant or nursing, consult your physician before taking this product.

References

1. 1. Swaminathan R. Magnesium metabolism and its disorders. The Clinical biochemist Reviews. 2003;24(2):47-66.
2. 2. Skalny AV, Mazaletskaya AL, Ajsuvakova OP, Bjørklund G, Skalnaya MG, Chernova LN, Skalny AA, Tinkov AA. Magnesium status in children with attention-deficit/hyperactivity disorder and/or autism spectrum disorder. Journal of the Korean Academy of Child and Adolescent Psychiatry. 2020 Jan 1;31(1):41-5.
4. 3. Mousain-Bosc M, Roche M, Polge A, Pradal-Prat D, Rapin J, Bali JP. Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. Magnesium research. 2006 Mar 1;19(1):46-52.
6. 4. Omotosho IO, Akinade AO, Lagunju IA. Calcium and magnesium levels are down regulated in Nigerian children with autism spectrum disorder and cerebral palsy. Neuroscience and Medicine. 2018 Aug 10;9(3):159-70.
8. 5. Mousain-Bosc M, Siatka C, Bali JP. Magnesium, hyperactivity and autism in children. In Magnesium in the Central Nervous System [Internet] 2011. University of Adelaide Press.
10. 6. Strambi M, Longini M, Hayek J, et al. Magnesium profile in autism. Biological trace element research. 2006;109(2):97-104.
12. 7. Huss M, Völp A, Stauss-Grabo M. Supplementation of polyunsaturated fatty acids, magnesium and zinc in children seeking medical advice for attention-deficit/hyperactivity problems - an observational cohort study. Lipids in health and disease. 2010;9(1):105.
14. 8. Baza F, Ahmed H, Zahra S, Mahmoud R. Magnesium supplementation in children with attention deficit hyperactivity disorder. Egyptian Journal of Medical Human Genetics. 2015;17.
16. 9. Schutte, SA, Lashner BA, and IY Janghorbani. Bioavailability of magnesium disglycinate vs. magnesium oxide in patients with ileal resection. J Parent Ent Nutr, 18:430-435, 1994.
18. 10. Roussouw J, Brummelen R. The bioavailability of four magnesium preparations. Publication pending.
20. 11. Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press, 1997.
22. 12. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.
24. 13. Rude RK. Magnesium. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, Mass: Lippincott Williams & Wilkins; 2012:159-75.
26. 14. Dickinson HO, Nicolson D, Campbell F, Cook JV, Beyer FR, Ford GA, Mason J. Magnesium supplementation for the management of primary hypertension in adults. Cochrane Database of Systematic Reviews 2006: CD004640.
28. 15. Del Gobbo LC, Imamura F, Wu JHY, Otto MCdO, Chiuve SE, Mozaffarian D. Circulating and dietary magnesium and risk of cardiovascular disease: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 2013;98:160-73.
30. 16. Larsson SC, Wolk A. Magnesium intake and risk of type 2 diabetes: a metaanalysis. J Intern Med 2007;262:208 14.
32. 17. Rodriguez-Moran M, Simental Mendia LE, Zambrano Galvan G, Guerrero- Romero F. The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnes Res 2011;24:156-62.
34. 18. Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H. Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med 2007;167:956–65.
36. 19. Rude RK, Singer FR, Gruber HE. Skeletal and hormonal effects of magnesium deficiency. J Am Coll Nutr 2009;28:131–41.
38. 20. Tucker KL. Osteoporosis prevention and nutrition. Curr Osteoporos Rep 2009;7:111-7.