GUT IMMUNE PROTECT
Gut Immune Protect is the only purified, dairy-free source of immunoglobulin G (IgG) available as a dietary supplement. Serum-derived bovine immunoglobulins (SBI) provide the highest IgG concentration available for GI and immune challenges where allergens are a signicant concern. Pure IgG helps to maintain a healthy intestinal immune system by binding a broad range of microbes and toxins within the gut lumen, thereby promoting their destruction and removal from the body. Gut Immune Protect provides 1,200 mg IgG in a one- scoop serving.
Autoimmunity is on the rise globally, and recent research demonstrates a connection between autoimmunity and intestinal permeability. Furthermore, many children with attention deficit hyperactivity disorder (ADHD), autism, and other forms of neurodevelopmental delays tend to suffer from digestive issues including increased intestinal permeability (leaky gut).1, 2 If intestinal permeability continues to progress, harmful substances begin to pass into the bloodstream and the immune system becomes overactive, which causes children to experience intestinal discomfort that worsens psychiatric symptoms. 3, 4 The discovery that the gut barrier plays a key role in immune health fueled the search to strengthen it. In that search, researchers found that the binding capabilities of immunoglobulins have a positive effect on gut barrier function. 5 Immunoglobulins bind microbes and toxins in the GI tract and eliminate them prior to immune system activation. As these unwanted triggers are removed, it resets healthy immune tolerance and builds a stronger barrier to the external environment. This is a key process in reducing psychiatric symptoms that are linked to neurodevelopmental disorders (e.g., ADHD, ASD), and in doing so makes immunoglobulin supplementation beneficial for children with such disorders.
Gut Immune Protect and GI Health
The GI tract acts as the gateway to the rest of the body, making the health of the gut barrier critical to overall health. Environmental triggers like poor diet, high stress and toxin exposure can lead to GI challenges. Furthermore, individuals with behavioral, psychosocial and neurodevelopmental disorders tend to experience nutritional deficiencies, in addition to increased intestinal permeability, that worsens behavioral symptoms and overall health. 6, 7 In practice, probiotics are a natural choice for supporting beneficial bacteria in the gut, but supplementation to eliminate unwanted microbes should also be considered. Gut Immune Protect has been shown to bind microbes and toxins, further enhancing microbiome balance and facilitating gut barrier strength.8, 9 Broad- spectrum binding capabilities (See Table 1) demonstrate the positive influence of nonallergenic forms of immunoglobulins .1 As seen in several studies, Gut Immune Protect has the potential to bind many types of microbes and toxins.5 This binding and elimination decreases microbe and toxin encounters by the immune system and resets immune tolerance.8, 9 In addition to improving immunity, Gut Immune Protect also helps target digestive issues such as diarrhea, while restoring the GI tract's ability to properly absorb and use essential nutrients.10 These properties not only improve immune system response, but also promote detoxification and the proper absorption of nutrients; all of which are factors that improve digestive function in children with neurodevelopmental disorders as well as their social, behavioral, and communication skills.6, 7
Gut Immune Protect and Immune Health
Occasionally, the immune system becomes overactive and immune tolerance drops. When immune tolerance is lost, the checks and balances of antibody production can be affected. To reestablish immune tolerance and appropriate activation, the burden on the immune system must be reduced. Reducing the reasons to respond allows the tissue to maintain normal inflammatory balance and creates an environment for normal tissue repair and immune reconstitution. 11, 17 Gut Immune Protect restores both immune system and GI function, which are vital for optimal physical and mental health in children with psychosocial, developmental, and behavioral disorders. In studies evaluating the effect of SBI on immune function, subjectsshowedpositiveoutcomesinseveralareas,including inflammatory balance, gut barrier function and immune cell counts.7,8,9 In an open-label human clinical study, GI-challenged patients were given 2.5 mg SBI twice daily. They had increased CD4+ counts in the duodenum after eight weeks, indicating a regenerative effect on the tissue and immune function in the intestines. In a large, multicenter, placebo-controlled follow- up study,8 SBI led to significant increases in peripheral CD4+ cells, when compared to placebo-controlled subjects. Findings of immune reconstitution in these patient demographics is promising for the future of establishing a healthy immune system in patients with GI and immune challenges.
1 scoop (2.5 grams) in 4 ounces of water or the beverage of your choice 2 times daily or as recommended by your health care professional.
Gut Immune Protect Dosage Instructions
Start at a low dose and slowly work up to the recommended dosage over 1-2 weeks. Mix powder with approx. 4oz of beverage of choice.
Does Not Contain
Gluten, corn, yeast, artificial colors and flavors.
If you are pregnant of nursing, consult your health care professional before taking this product.
- 1. Molloy CA, Manning-Courtney P: Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism. 2003;7(2):165-171.
- 2. Ming X, Chen N, et al. A Gut Feeling: A Hypothesis of the Role of the Microbiome in Attention-Deficit/Hyperactivity Disorders. Child Neurol Open. 2018;5:2329048X18786799.
- 3. Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clin Gastroenterol Hepatol. 2012;10(10):1096-100.
- 4. Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011; 91(1):151-75.
- 5. Detzel CJ, Horgan A, Henderson AL, Petschow BW, Warner CD, Maas KJ, Weaver EM. Bovine Immunoglobulin/Protein Isolate Binds Pro-Inflammatory Bacterial Compounds and Prevents Immune Activation in an Intestinal Co-Culture Model. PLOS One 10(4) April 2015; DOI:10.1371/journal.pone.0120278
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- 8. Jasion VS, Burnett BP. Survival and Digestibility of Orally- Administered Immunoglobulin Preparations Containing IgG Through the Gastrointestinal Tract in Humans. Nutrition Journal 2015;14:22 DOI 10.1186/s12937-015-0010-7.
- 9. Petschow BW, Burnett B, Shaw AL, Weaver EM, Klein GL. Serum-derived bovine immunoglobulin/protein isolate: postulated mechanism of action for management of enteropathy, Clin Exp Gastroenterology. 2014;7:181- 190.
- 10. Dale W. Evaluation of serum-derived bovine immunoglobulin protein isolate in subjects with diarrhea-predominant irritable bowel syndrome. Clin Med Insights Gastroenterol. 2013;6:49-50.
- 11. Perez-Bosque A, Miro L, Maijo M, Polo J, Campbell J, Russell L, et al. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. American journal of physiology Gastrointestinal and liver physiology. 2015;308(12):G1012-8.
- 12. Henderson AL, Brand MW, Darling RJ, Maas KJ, Detzel CJ, Hostetter J, et al. Attenuation of Colitis by Serum-Derived Bovine Immunoglobulin/Protein Isolate in a Defined Microbiota Mouse Model. Digestive diseases and sciences. 2015;60(11):3293- 303.
- 13. Wilson D, Evans MD, Weaver E, Shaw AL, Klein GL. Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in
- Subjects with Diarrhea-Predominant Irritable Bowel Syndrome. Clinical Medicine Insights: Gastroenterology. 2013;6:49-60.
- 14. Asmuth DM, Ma ZM, Albanese A, Sandler NG, Devaraj S, Knight TH, et al. Oral Serum- Derived Bovine Immunoglob¬ulin Improves Duodenal Immune Reconstitution and Absorption Function in Patients with HIV Enteropathy. Aids. 2013;27:2207-17.
- 15. Asmuth DM, Somsouk M, Hunt P, Ma ZM, Miller CL, X.D., Hinkle J, et al. Serum-Derived Bovine Immunoglobulin Protein Isolate Increases Peripheral and Mucosal CD4+ T-cell counts in Patients with HIV Enteropathy. 8th IAS Conference on HIV Pathogenesis, Treatment and
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- http://www.ias2015.org/WebContent/File/IAS_2015__MED2. pdf; 2015.
- 17. Bosi P, Casini L, Finamore A, Cremokolini C, Merialdi G, Trevisi P, et al. Spray-dried plasma improves growth perfor¬mance and reduces inflammatory status of weaned pigs challenged with enterotoxigenic Escherichia coli K88. Journal of animal science. 2004;82(6):1764-72.